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Barbiturates have little analgesic action at subanesthetic doses. Rather, in subanesthetic doses these drugs may increase the reaction to painful stimuli. All barbiturates exhibit anticonvulsant activity Con anesthetic doses.
Reports of infants suffering from long-term barbiturate exposure Con utero included the acute withdrawal syndrome of seizures and hyperirritability from birth to a delayed onset of up to 14 days. (See “Drug Abuse And Dependence” section.)
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Excipients Per commercially available drug preparations may have clinically important effects Per mezzo di some individuals; consult specific product labeling for details.
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Barbiturates including pentobarbital are addictive and have been historically misused and abused illegally as street drugs. Pentobarbital abuse can lead to tolerance, dependence, and overdose, and cause withdrawal symptoms such as tremors, difficulty sleeping, and agitation upon discontinuation.
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Pentobarbital is not used widely Per clinical medicine because of its poor safety profile, habituation, and lack of an antidote. All prescribing clinicians should be aware of the drug's toxicity and adverse event profile. Neurologists can more info use pentobarbital for refractory status epilepticus.
To avoid the high potential for morbidity and mortality associated with pentobarbital, the pharmacist should recommend prescribing clinicians safer alternative agents. Nurses should monitor the patient at subsequent pentobarbital sodium visits, verifying medication compliance and treatment effectiveness.
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The effect of the resultant decreased blood levels of griseofulvin on therapeutic response has not been established. However, it would be preferable to avoid concomitant administration of these drugs.
Use with caution; should not be used Per mezzo di patients with marked hepatic impairment, including patients with premonitory signs of hepatic coma.
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